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Reference Mehler, Yager and Solomon15,Reference Gibson, Workman and Mehler16 Our patient lost approximately 20 kg in 6 months, similar to the patient of Guerdjikova et al, Reference Guerdjikova, Ward, Ontiveros and McElroy27 which was more weight than the average weight loss reported in clinical trials of semaglutide

doi: 10.1038/84818

Many patients start noticing weight loss within the first few weeks of treatment, but significant results typically appear after reaching the maintenance dose around 16 to 20 weeks

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As might be expected, hypoglycaemic episodes were more common in patients receiving background insulin and sulphonylurea