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Inadequate sleep interferes with the recovery of bodily functions, leading to reduced productivity and increased risk of cardiovascular disease, obesity and diabetes

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10.1016/S0140-6736(19)32984-8 135

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A study based on Nrf2-KO (knockout of Nrf2) diabetic mice showed that syringaresinol inhibits pyroptosis caused by NLRP3/Caspase-1 in DN by activating the Nrf2/HO-1 signaling pathway [72]

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Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults

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Furthermore, urothelium from individuals with IC has demonstrated reduced cell proliferation and increased cell permeability (Fiehn and Kim, 2014)

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