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While early anecdotal evidence suggested significant clinical symptomatic improvements, the five clinical trials identified in a recent meta-analysis used small populations with different clinical syndromes, measured different outcomes, and yielded no overall evidence of benefit [109]

When cells are exposed to increased levels of oxidative stress, GSSG accumulates and the ratio of GSH/GSSG decreases to ratios as low as 10:1 and even 1:1

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Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis

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