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Doubling your dose leads to rapid accumulation of the medication, causing your body to mount a strong counter-regulatory response that actually slows weight loss and triggers severe side effects

Mild side effects like light nausea or reduced endurance during the first month typically improve as your body adapts

Adequate nutrition, hydration and preservation of lean mass remain important considerations in weight-loss research

These methods can help sustain adequate B12 levels and are often more convenient for long-term use

The pathophysiology involves complex neurological changes, including sensitization of pain pathways and alterations in central pain processing mechanisms