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Looking ahead, Al-Aly said, the findings support the case for clinical trials to test GLP-1 medications as treatments for addiction in their own right, including trials powered to measure effects on overdose and drug-related death

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Dula also significantly reduced the expression of transforming growth factor-1 (TGF-1), phosphatidylinositol-3-kinase (PI3K), protein kinase B (AKT) signaling pathway, and the inflammatory cytokines: nuclear factor kappa B (NF-B), interleukin-6 (IL-6), and interferon- (IFN-) in colonic cellular structures

Across all groups, fasting insulin levels decreased, suggesting improved insulin sensitivity

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