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The control group received the drugs vehicle (0.5% acetic acid with distilled water and injected subcutaneously in a volume of 1 mL/kg) and intravenous (IV) physiological saline in the tail for three days and continued to receive daily injections at noon for two weeks, starting on the fifth day

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In addition, noradrenaline and serotonin (which are involved in the central inhibition of pain) are decreased, which may also explain why FMS patients have a higher risk for the development of depression and anxiety disorders