Unlike earlier GLP-1 receptor agonists, retatrutide is a triple agonist : GLP-1 receptor agonist suppresses appetite, slows gastric emptying, improves insulin sensitivity GIP receptor agonist enhances insulin release, amplifies GLP-1 effects Glucagon receptor agonist stimulates energy expenditure, fat metabolism, and potentially impacts lipid handling Clinical trials so far have shown remarkable weight loss (up to 24% in some studies) and strong metabolic improvements, including effects on lipids like LDL cholesterol
Increased activity sustains more weight loss, which amplifies your physical capacity
Here's the science bit: drugs like Ozempic, WeGovy and Mounjaro work as GLP-1 agonists - essentially, they mimic the effects of our natural GLP-1 production, meaning they can help treat obesity and conditions such as diabetes, and insulin sensitivities such as polycystic ovarian syndrome (PCOS)
However, among other effects, it is in part able to suppress nausea, by acting directly on the Area Postrema, (the same part of the brain that we introduced which regulates vomiting in humans) [24] , which is thought to be a contributing factor as to why dual GLP1R/GIPR agonists are able to act synergistically
But they have yet to identify the species