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Examining the risk of depression or self-harm associated with incretin-based therapies used to manage hyperglycaemia in patients with type 2 diabetes: a cohort study using the UK Clinical Practice Research Datalink

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The strategic differentiation thesis that emerged from the analysis: CT-388 is best positioned as the "Balanced Precision Dual Agonist," differentiated from tirzepatide by equimolar GIP:GLP-1 engagement (1:1 vs 9:1), a distinct peptide scaffold with independent IP, and a five-year extended exclusivity window