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Like testosterone levels, older adults experience a lower basal level of IGF-1 (the so-called somatopause which refers to the diminishment of the GH-IGF-1 system) which attenuates post-RE levels of IGF-1 (Kraemer et al., 1999)

It notes case reports of thyroid changes where causality was not established

Whereas CD5 and IL-2 influence immune system functions and MMP2 is important in maintaining the extracellular matrix in skin, tendons and other connective tissue, and Tram1 increases protein production