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NMR Structural Resolution of FOXO4-DRI/p53TAD2 Complex (Nature Communications, 2025) Disordered-to-Ordered Complex Formation: Structural Basis of FOXO4-DRIs Senolytic Mechanism A landmark structural study published in Nature Communications (2025) resolved the solution NMR structural models of the p53 transactivation domain (TAD2) in complex with the FOXO4 forkhead domain and with FOXO4-DRI

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doi: 10.1161/ATVBAHA.117.309253 171

PIEDs also gained huge media attention across the Tasman in February 2013, when an Australian Crime Commission report linked organised crime to providing these substances to professional AFL and league players

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