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Recently, ground-breaking studies conducted in OVX models show proof-of-principle that microbiome-targeted therapeutic modalities can be leveraged to successfully inhibit peripheral 5HT biosynthesis and ameliorate estrogen-deficiency-induced bone loss, along with concomitant modulation of neurobehavioral functions (300, 301)

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You should be especially cautious if you have a history of pancreatitis, gallbladder disease, liver disease, diabetes, frequent low blood sugar, heavy alcohol use, or medications that should not be mixed with alcohol