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If gastrointestinal symptoms are intolerable despite optimal management strategies, alternative medications may be available

Ren Y, Chen Y, Zheng W, Kong W, Liao Y, Zhang J, Wang M, Zeng T

The difference of 0.03 mg is clinically insignificant for most people

While this variety offers more choices, it also creates confusion about what actually works and what is safe for long-term use

The International Association for the Study of Pain defines it as pain resulting from a stimulus that does not normally provoke pain, and that definition matters because it distinguishes allodynia from hyperalgesia, where painful stimuli simply hurt more than expected