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Interestingly, 7 days of relatively low Mn exposure reduced TH-expressing cells in neuron-glial cultures, not in neuron cultures alone, indicating glial cells may exacerbate Mn toxicity in neurons (Zhang et al., 2010)

In conclusion, the current study revealed that arogenate-specific TyrA a enzymes evolved in some bacterial lineages, through the acquisition of an acidic residue at the 222 position, which later gave rise to the TyrAs of algae and land plants likely through a novel HGT event