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The body's metabolic adaptations to weight lossincluding decreased energy expenditure, increased hunger hormones, and reduced satiety signalspersist long after weight reduction, making weight maintenance challenging without continued intervention

Dennis LK, Vanbeek MJ, Beane Freeman LE, Smith BJ, Dawson DV, Coughlin JA

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Firstly, it is not clear how much GIPR stimulation contributes to the effects of tirzepatide, and what should be the ideal ratio of GIP/GLP-1 action of this co-agonist for the best results