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Complex pharmacological animal models suggest that the peptide interacts intricately with multiple neurotransmitter networks, including the dopaminergic, serotonergic, GABAergic, and opioid systems

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The presence of copper ions in cells serves a dual function

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Following its dissociation from the a 2 -macroglobulin, the peptide is proteolytically cleaved to generate a C-terminal pentapeptide, which activates an intracellular Gi-protein-MAP kinase signalling pathway [232, 233]

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(PubMed) Campone M, Berton-Rigaud D, Joly-Lobbedez F, et al

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Matrix Biology Research applicable for research models studying extracellular matrix-related processes under controlled conditions

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