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It is FDA-approved as Ozempic (2017), Wegovy (2021), and Rybelsus (2019, oral formulation), and serves as the reference compound for the broader class of long-acting GLP-1 receptor agonists

Chin J Liver Dis 2021;13:46-53

Four found energy intake to be significantly reduced, whereas the remaining studies failed to find an effect again potentially due to limited statistical power and also low GLP-1 infusion rates

Any side effects that disrupt daily life or feel intense should be reported to a medical professional

Landmark trials include STEP (semaglutide for weight management, NEJM 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)