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The dose is gradually increased based on blood sugar response and tolerance, usually at intervals of one to two weeks

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Circ Res 90:966973 Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C et al (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

Schvartsman G, Ma J, Jr BR, Haydu LE, Amaria RN, Hwu P, Hwu WJ, Diab A, Patel SP, Davies MA , Tawbi HAH

Obstructive nephropathy: Insights from genetically engineered animals