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Disease-anchored panels and how to act on them For disease-anchored panels, tailor the readouts to the biology and act on the map they provide: in cardiovascular/vascular beds, pair DHE-HPLC (to quantify O 2 ) with compartment-targeted HyPer for H 2 O 2 , then add F 2 -isoprostanes/3-nitrotyrosine and iron indices to distinguish NOX-driven endothelial dysfunction (O 2 ONOO lowering NO bioavailability) from mitochondrial bursts typical of ischemiareperfusion (Bkgaard Nielsen et al

These diverse mechanisms underscore their potential as nontoxic adjuvants and therapeutic agents in future cancer treatment strategies (140)

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Pharmacol Res 44:491495 [DOI] [PubMed] [Google Scholar] Cadenas E (1989) Biochemistry of oxygen toxicity