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GLP-1 drugs had been in shortage since 2022 due to increased demand, and a law allowed compounding pharmacies to step in to fill supply gaps during those years

2013;231(2):456-61 [6] Brown BE, Kim CH et al

Furthermore, there is good reason to think that Novo Nordisks patents on semaglutide may be vulnerable

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In the docking analysis with the GLP-1 receptor, it can be seen that the nGLP1-DARPin fusion protein had a higher binding affinity to the GLP-1 receptor (G = 6.1 kcal mol 1 ) compared with the mGLP1-DARPin-1 (G = 5.5 kcal mol 1 ) and mGLP1-DARPin-2 (G = 5.8 kcal mol 1 ) fusion proteins (Table 3, Fig