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As such, the model was used to simulate how long it would take pharmacologically and toxicologically relevant concentrations of doxorubicin to yield a 70% reduction in GSH concentration, indicative of impaired cellular antioxidant defence, protein binding and cell death 19

Studies show that therapy-resistant fibromyalgia patients reported reductions in chronic pain and chronic fatigue associated with the condition, and improved ability to function through their daily activities

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The polar and charged residues lining the enzymes binding pocket likely contribute to the formation of an electrostatic environment essential for substrate interaction (Suyal et al., 2023)