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Neurological Relevance Preclinical evidence suggests broader neuroprotective potential: In traumatic brain injury models, SS-31 reduced mitochondrial swelling, neuronal loss, and neuroinflammation Aged mice treated with SS-31 showed significantly improved exercise tolerance, muscle strength, and mitochondrial efficiency Studies demonstrate protection against ischemic injury and enhanced cardiac output Phase 3 trials are ongoing for dry age-related macular degeneration and primary mitochondrial myopathy (Stealth BioTherapeutics pipeline) Implications for Brain Aging Mitochondrial dysfunction is a hallmark of brain aging and neurodegeneration

Authors' contributions HN, MR, JJ, and CM formulated the questions and contributed substantially to the design of the project

Following incubation in protease III for 30 min at 40 C, sections were incubated in a probe recognising murine mRNA for Glp1r (ACD, Cat #418851-C2) at 40 C for 2 h

Starting, stopping and restarting Lexapro many times over increases the risk of weight gain

Metabolic effects: GLP-1 improves insulin sensitivity and glucose metabolism, independent of weight loss