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Description

UBX0101 (MDM2 inhibitor, Unity Biotechnology) targeted p53-MDM2 interaction in senescent cellsPhase 2 for knee OA failed in 2020

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Zhang Y, Gao J, Chung KK, Huang H, Dawson VL, Dawson TM (2000) Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

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95% CI, 1.06 to 1.21) compared to SGLT-2 inhibitor therapy with insulin [93]

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The logic behind combining Cagrilintide with a GLP-1 agonist is straightforward

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