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The Arg3 substitution is the critical functional modification because position 3 falls within the IGFBP binding domain, and the charge reversal from acidic glutamate to basic arginine disrupts the electrostatic complementarity required for high-affinity IGFBP interaction

The compound's potential impact on dopamine pathways also opens avenues for research into reward systems and addiction, adding another layer of complexity and potential application

Acetic acid is, well, an acid

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AOD-9604 also inhibits lipogenesis, the synthesis of new fat, adding a second metabolic angle