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In a two-step procedure, 2-hydroxymalondialdehyde is firstly condensed with p -aminobenzoyl-L-glutamic acid, forming a diimine, which subsequently reacts with triamino-pyrimidinone to obtain folic acid

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Acknowledgements This paper was funded by grants from the National Natural Science Foundation of China (82070588, 82370577), National Key R&D Program of China (2023YFA1800801)