doi:10.1016/j.japh.2023.10.037 162
For some women, the medication feels strongest early in the cycle and less predictable before the period
Side-by-Side Comparison FDA Approved Tesamorelin Yes (Egrifta, 2010) CJC-1295/Ipamorelin No (compounded) Tesamorelin/Ipamorelin No (compounded combo) Mechanism Tesamorelin GHRH receptor (single pathway) CJC-1295/Ipamorelin GHRH + ghrelin receptor (dual pathway) Tesamorelin/Ipamorelin GHRH + ghrelin (FDA molecule + dual pathway) Half-Life Extension Tesamorelin DPP-IV protection (~26 min) CJC-1295/Ipamorelin Enzyme-resistant substitutions (~30 min, no-DAC) Tesamorelin/Ipamorelin DPP-IV protection + ghrelin receptor Clinical Evidence Tesamorelin 2 Phase 3 RCTs, 816 patients CJC-1295/Ipamorelin Phase 2 (CJC-1295) Tesamorelin/Ipamorelin Individual components well-studied Fat Loss Data Tesamorelin 15% visceral fat reduction (CT-measured) CJC-1295/Ipamorelin Body composition improvement (practitioner data) Tesamorelin/Ipamorelin Combined mechanisms Liver Fat Tesamorelin 35% normalized liver fat (Lancet HIV, 2019) CJC-1295/Ipamorelin Not specifically studied Tesamorelin/Ipamorelin Tesamorelin component covers this Sleep Benefit Tesamorelin Moderate CJC-1295/Ipamorelin Strong (dual-pathway overnight GH) Tesamorelin/Ipamorelin Strong Regulatory Pedigree Tesamorelin Strongest (current FDA approval) CJC-1295/Ipamorelin Standard compounded Tesamorelin/Ipamorelin FDA molecule + compounded Tesamorelin: The FDA-Approved Option Tesamorelin has the strongest clinical evidence of any growth hormone peptide
Potential side effects may include nausea, vomiting, constipation, diarrhea, upset stomach, injection site irritation, low blood sugar in certain settings, and allergic reactions
When it comes to measuring vitamin B12 levels in the blood, normal values typically range from 160 to 950 picograms per millilitre (pg/mL) or 118 to 701 picomoles per litre (pmol/L) 3
