BH4 treatment resulted in an increase in methionine but this increase was only borderline significant [ F (1, 26) = 3.91, p = 0.06
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And so with particularly with the the oral versions, you know, when they come out, you know, there there will absolutely be a critical need to make sure that theres appropriate, you know, utilization management so that these drugs, you know, can be, you know, available to those that that need them the most and also that that theyre being used appropriate safely and appropriately from a clinical perspective