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Funding National Council for Scientific and Technological Development (CNPq, MCTI, Brazil) grant number 406484/2022-8 (INCT BioOncoPed)
Others have reported that IC/BPS patients with Hunner lesions are older and more likely to have other comorbid pain syndromes, and that those patients without Hunner lesions more likely to have pelvic floor dysfunction and myofascial pain (
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Studies suggest that the combination of vitamin E with psoralen and ultraviolet A (PUVA) phototherapy may prevent oxidative disorders resulting from PUVA therapy, but did not improve clinical improvement of vitiligo lesions [91]
The FDA explicitly warns against using illegally marketed or compounded drugs without proper medical oversight, emphasizing the critical safety advantage of regulated pharmaceuticals over unregulated supplements like berberine
