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The institute recommended that existing GLP-1 makers, and those with products in the pipeline, should consider steep discounts to prices in exchange for higher volume. What has to happen is we have to move from a low-volume, high-price business model, to a high-volume, low-price business model, Nunn said

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Like other GLP-1 pathway drugs, orforglipron interacts with peripheral and central signaling to regulate appetite and metabolism, including delayed gastric emptying and improved post-prandial control