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Looking forward, the most impactful advances in peptide therapeutics are likely to emerge from the systematic re-examination of known biology rather than from the discovery of entirely new hormones ( In conclusion, underexplored peptidereceptor systems constitute a vast and largely untapped reservoir of therapeutic potential

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We also assess the potential mechanisms that contribute to the reduction in major adverse cardiovascular events in individuals treated with GLP1R agonists and highlight the emerging cardiovascular biology of novel GLP1-based multi-agonists currently in development

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