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Benefits: *increases calcium absorption *increases muscle protein *increases hormones enzymes and antibodies Risks when deficient: *increases stress induced anxiety *decreases digestion Vitamin C have shown improvements in physical, mental, and emotional functions, symptoms of fatigue, nausea and vomiting, pain, and appetite loss

A 12-week multicenter randomized controlled trial provided strong evidence that for elderly people with sarcopenia or potential sarcopenia, the intervention of combined muscular-targeted oral nutritional supplements (rich in protein, HMB and vitamin D3) and structured exercise programs (including twin-weekly resistance training and interday chair exercises) compared with the control group It can more effectively improve the lean tissue of the limbs, skeletal muscle index, grip strength, walking speed, chair standing performance and quality of life [69]

It calls for coordinated research, regulatory action, professional engagement and equitable, timely adoption of effective therapies

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It is determined in part by physicochemical properties