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To test whether spike-induced loss of apical CFTR was due to failure of recovery from endosomal recycling, we used an impermeant biotin labelling method to ask how much CFTR from the apical surface was returned to the apical surface after exposure to progressively increasing concentrations of spike protein

Willekens FL, Werre JM, Kruijt JK, Roerdinkholder-Stoelwinder B, Groenen-Dpp YA, van den Bos AG, et al

The discontinuation rates tell the most important part of the story

Wegovy urinary incontinence is often assumed to be a direct side effect, when in reality it is not typical for most people using the medicine