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The starting dose of tirzepatide is 2.5 mg once a week, and after 4 weeks, the dose is increased to the therapeutic dose of 5 mg and administered subcutaneously in patients with T2D

The classical example of this was the recognition that an APAP overdose in the mouse causes the formation of a reactive metabolite, which first depletes glutathione (GSH) and then binds to sulfhydryl groups of proteins triggering cell death [79]