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Fig.4 Principle diagram of solid phase peptide synthesis (SPPS) Based on the molecular design disparity, upstream expression platforms for biology fermentation includes E.coli expression, yeast expression system and CHO cell expression system

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LCA, lithocholic acid

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Specifically, given that SCFAs function as natural inhibitors of HDACs (as detailed in Section Histone Modifications), the direct administration of pharmacological HDAC inhibitors can simulate the epigenetic effects of butyrate 100,154,155

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