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Glucagon is also involved in acutely regulating glucose homeostasis and administration of pharmacological doses of glucagon in animal models for diabetes or obesity has demonstrated regulatory effects on lipid metabolism, energy expenditure, and food intake (41, 50)

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Considering the filters outlined in Figure 30 and the compounds analyzed in this study, including the three reference drugs allopurinol, febuxostat, and topiroxostat, Table 5 summarizes the filter violations and their respective causes

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