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Cancer The flavoprotein, methylenetetrahydrofolate reductase (MTHFR), plays a pivotal role in folate-mediated one-carbon metabolism

[DOI] [PubMed] [Google Scholar] 194.Emorine L, Blin N, Strosberg AD

The pivotal trial supporting its 2010 FDA approval enrolled 816 HIV-infected adults with clinically defined lipodystrophy, and Phase 3 data documented visceral fat reductions of roughly 15-18% over 26 weeks of treatment a result robust enough to clear FDA review for a defined medical indication

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In severe cases, individuals may become unconscious or slip into a coma