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In all closed-state KAR structures, apo or competitive antagonist-bound, the pore geometry in this region is strikingly similar, with the pore radii smaller than the diameter of a water molecule (Figure 7F)

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More than 6 million PDP enrolleesone-third of the totalare enrolled in the lowest-premium PDP in 2026 Among the 10 national PDPs available in 2026, the PDP with the lowest average monthly premiumWellcare Value Script, at just under $6has attracted a substantial share of all PDP enrollees, with one-third of PDP enrollees in non-group plans (6.1 million) (Figure 3)

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