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With Phase 3 trials ongoing in 2026 and growing patient curiosity, understanding the science behind weekly dosing has never been more important for anyone considering this medication

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283,284 Hyperglycemia activates NF-B signaling pathways, enhancing the expression of inflammatory genes and further amplifying the inflammatory response

The encoded PL involves the pancreatic lipase gene (PNLIP), which primarily acts in the duodenum by hydrolyzing triglycerides into monoacylglycerols and fatty acids [17]