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Do not double up on doses to compensate, as this can intensify side effects without accelerating benefits

However, based on what is known about each substance individually, there are certain risks to consider: GI side effects: The most common side effects of Wegovy are GI in nature

Over the past decade, it has been used in the United States for a variety of reasons, including as an opioid alternative, to self-medicate for substance abuse disorders, and to self-manage chronic pain

Bupropion has a half-life of about 21 hours, and its active metabolites have half-lives up to 37 hours

However, many patients also present non-gastrointestinal symptoms such as headache, fatigue, joint and muscle pain, numbness or tingling of the extremities, eczema or skin rash, anxiety, depression, and brain fog