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Cellular effects duration vs plasma half-life Critical distinction: Plasma half-life duration of effects GHK-Cu clears blood in hours But cellular effects last days How GHK-Cu works: Peptide binds to cell surface receptors Triggers intracellular signaling cascades Activates gene expression changes Initiates collagen synthesis, wound healing, etc

Intranasal administration leverages the highly vascularised nasal mucosa for systemic absorption

This leads to higher treatment success rates, fewer side effects, and improved patient outcomes

Histology and Immunohistochemistry Mouse tissues were fixed in 4% paraformaldehyde for 24 h

doi :10.1016/0891-5849(94)90029-9