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Excessive copper exposure is a theoretical concern with long-term, high-dose use
These mechanisms are not redundant but sequential: vessels deliver nutrients (BPC-157), cells migrate and repair (TB-500)
In vitro measures show that extended wakefulness (i.e., sleep deprivation, SD) impairs hippocampal LTP dependent on cAMP/PKA/CREB signaling, but not LTP that requires new translation (Vecsey et al., 2009)
Researchers planning new work should review the most current literature before designing protocols, with attention to the gap between preclinical breadth and clinical-trial depth
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