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Week 4 FirstMonth Milestones At this point, progress becomes visible

Each person receives a tailored plan that takes into account their unique health conditions, lifestyle, and goals

Tapering versus abrupt cessation The clinical trials did not specifically study tapering protocols, but physiological principles suggest a gradual dose reduction may produce a smoother transition than abrupt cessation

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This is consistent with microgravity-induced overproduction of ROS, leading to oxidative stress and DNA damage, which compromise endothelial cell function and cause the vascular pathologies observed in astronauts 5