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7.2.1 Prodrug Design SAG adopts advanced prodrug technology, a mature approach widely used in the pharmaceutical industry

Our later studies on the Shank3 -/- and Cntnap2 -/- knockout mice, the human SH-SY5Y cell line, and the human induced pluripotent stem cellsderived cortical neurons isolated from patients carrying a SHANK3 mutation confirmed the increased levels of NO and protein SNO [172176]

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Side effects can often be mitigated by correctly titrating your dosage upward, so youll want to ensure that you are taking the medication exactly as prescribed by your provider to minimize risk and/or severity of side effects