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The stiffness lasts an hour, sometimes two

In a review of RCTs that compared thiazolidinediones with placebo for the secondary prevention of stroke and related vascular events in people who had experienced stroke or transient ischaemic attack, thiazolidinedione treatment reduced the recurrence of stroke compared with placebo 114

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In the 12 mg arm, participants achieved a mean body weight reduction of approximately 24% at 48 weeks the highest observed across the dose groups though this arm was also associated with a higher incidence of gastrointestinal side effects