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In N171-82Q transgenic mice, exenatide improved motor function, prolonged survival, normalized glucose metabolism, and reduced mHTT aggregation in brain and pancreatic tissue (58, 174)

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Interestingly, in chronically insulin treated 3T3-L1 cells and fat explants from insulin resistant mice, only insulin-stimulated glucose uptake is decreased while insulin suppression of lipolysis is intact (121), effects which are explained by selective insulin resistance in adipocytes

Another study published in Diabetes Care showed that combining semaglutide with vitamin B12 supplementation led to improvements in insulin sensitivity and glucose metabolism, making it an effective option for individuals with prediabetes or type 2 diabetes

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