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Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus

Gradual escalation over 16 to 20 weeks is the standard clinical protocol precisely because it minimizes GI symptoms while still reaching a therapeutic dose

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2024 Meta-Analysis Indicates That GLP-1RAs Reduce Adverse CV Events GLP1-RA therapy significantly reduces the risk of major adverse cardiovascular events (MACEs), all-cause mortality, CV mortality, stroke, risk for coronary revascularization, and composite adverse kidney outcomes in both sexes, regardless of a patient's history of cardiovascular disease, BMI or eGFR (Rivera et al, 2024)

Many Found members also describe a quieting of "food noise" the persistent, low-level mental preoccupation with food and eating that makes changing habits so difficult