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Polyphenols can inhibit AP-1 activity by (i) blocking the binding of AP-1 to DNA, (ii) inactivating the AP-1 proteins, and (iii) interfering with the signal transduction pathways that activate AP-1 [207]

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We utilized vitamins B1 , B5 , B6 , B7 , E , and GSH referred to cell reinforcements as expected inhibitors against M pro , by performing docking via Autodock Vina and Discovery Studio Visualizer (DSV) packages followed by molecular dynamics simulation (MDS) and MM/PBSA by GROMACS 5.0.4 ( (Abraham et al