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Current strategies for overcoming BM radioresistance primarily concern tuning of physical parameters of radiotherapy, such as dose fractionation, rather than using biologically targeted approaches

Covariates include age, BMI, systolic blood pressure, diastolic blood pressure, marital status, education level, smoking status, physical activity, total cholesterol and TAG

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

Schedule: Twice-weekly subcutaneous injections for 812 weeks (extend to 16 weeks if desired)

This approach provides a powerful stimulus and then allows the system to return to baseline