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[PubMed] [Google Scholar] 2.Pereira JM

If your goal is repletion, many clinicians start at 500 mg per day for 48 weeks, then move to 250 mg

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These include: Neurological symptoms : tingling or numbness in hands and feet (paraesthesia), difficulty walking, balance problems, memory difficulties, or mood changes Haematological signs : ongoing fatigue, weakness, pale skin, or shortness of breath suggesting anaemia hasn't resolved Glossitis : a sore, red tongue that hasn't improved Cognitive issues : continued difficulty concentrating or memory problems These symptoms, particularly progressive neurological deficits or severe anaemia with cardiorespiratory compromise, may require urgent medical attention