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1 Most were issued on September 9, 2025, but the FDA continues to publish new letters

Circ Res 126(2):280293 Chen L, Shi D, Guo M (2021) The roles of PKC-delta and PKC-epsilon in myocardial ischemia/reperfusion injury

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This isn't just inflation or trend, its a convergence of cost drivers - : 74% spike in $1M+ claims since 2021 - : providers are charging more : quietly adding 24% to premiums : GLP-1s and specialty drugs are reshaping budgets : demand is up, longer treatments, higher costs