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Lipophilicity, a critical property for drug permeability, is moderate to high across all lignans, as evidenced by their consensus LogP values, ranging from 3.53 (gomisin A) to 4.40 (schisandrin A)

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At the end of the reaction, wash the resin with 200mLx3DMF, add 200mL DBLKx2 for deprotection 5min+7min, wash the resin with 200mLx5DMF, and continue to couple Fmoc-Gly-OH, Boc-Glu(OtBu)-OH, Fmoc-Leu-OH, Fmoc in sequence according to the peptide sequence -Tyr(tBu)-OH, Fmoc-Ser(tBu)-OH, Fmoc-Ser(tBu)-OH, Fmoc-Val-OH, Fmoc-Asp(OtBu)-OH, Fmoc-Ser(tBu)-OH, Fmoc-Thr(tBu)-OH, Fmoc-Phe-OH, Fmoc-Thr(tB